. EVIDENCE : FOR A RECEPTOR : FOR MIF PRESEHT ON TtIE PERITONEAL
نویسندگان
چکیده
The capillary tube technique for assaying macrophage migration (1) has been widely used in studies on cellular immunity and has allowed a better understanding of lymphocyte-macrophage interaction associated with the expression of delayed hypersensitivity. The sensitive lymphocyte on exposure to specific antigen (2, 3) has been shown to produce a soluble effector molecule called migration inhibitory factor (MIF), 1 which has been characterized as an acidic glycoprotein with a molecular weight of 35,000-55,000 (4, 5). MIF inhibits the migration of the peritoneal macrophage, and recent evidence suggests that its primary biological function may be to activate macrophages (6). The mechanism of these actions is not understood.
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